The Fasciculus Medicinae (which was the first edition in Latin in 1491), contained a treatise on anatomy, on surgery, on gynecology and obstetrics, on urine, on phlebotomy, and on the plague.
We are eventually talking about the Black Death Plague here, which hit Italy in 1347 and reached Venice by January 1348.
There isn't much information about this "Plague Physician - year 1495" woodcut, but there are a couple things to be noted that make this image unlike many others:
Plague was rather common in those old times, but medicine had not yet found any feasible solution, the populations were relying basically on Religion and Destiny.